Inhibition of nitric oxide synthesis leads to reduced parasitemia in murine Trypanosoma brucei infection.
نویسندگان
چکیده
In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.
منابع مشابه
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عنوان ژورنال:
- Infection and immunity
دوره 62 5 شماره
صفحات -
تاریخ انتشار 1994